New drugs will act on specific cell components by Corina Ciubotaru

A recent U.S. study shows that it is possible to create a drug that can slow down the aging process by acting directly on the cells. They contain tiny organs called mitochondria that are responsible for the energy output and that sustain cellular life even if other components of the cell are destroyed. If cells are fed low-calorie food that is still high in nutrients, the mitochondria begin to produce more NAD, a substance that in turn stimulates enzymes made by genes known as SIRT3 and SIRT4. Under the action of these substances, the cells become stronger and the energy output increases, while the aging process is slowed. In the study, the number of cells dying for others to take their place in the regeneration process was also smaller, so scientists now think these genes will be targeted by future drugs capable of curing several illnesses. Diabetes, cancer and osteoporosis are only some of the diseases associated with old age that may be alleviated through these new generation pills that would act by producing beneficial stress on the cells. But whether or not they're going to make us live 200 years, remains to be seen. The company that released the results, named Sirtris Pharmaceuticals, had previously researched genes SIRT1 and SIRT2 and found their involvement in cell replacement. A drug named SRT501 was released to target these genes and now the development of a new type is underway, in light of the recent findings. The study was published in the journal Cell on September 21st.

related story: http://news.yahoo.com/s/nm/20070920/sc_nm/aging_drugs_dc;_ylt=Aoisktee2nrHktF1W.t1T5.s0NUE

by Corina Ciubotaru for PocketNews (http://pocketnews.tv)

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